Are all browsers configured to use the same dns servers, all on dot\doh? Have you verified they are consistently not blocking those servers? Are they all configured to not revert to default servers on failed attempts? Perhaps there is longer lasting dns caches in some of your software. What about proxy settings?

I’m just throwing stuff on the wall here.

Older, out of support, nvidia drivers tend to break from time to time.

I think that is a setting in freetube. Also some browser extensions can do that.

If this is just a rebranding; why does there need to be beta test?

Well, it does say that Nvidia does not allow a translation layer like this.