Since there’s no answer from Guix users over here, well, I use Guix as my main distro. The language choice is superior to Nix’s half-Haskell DSL. However, the bigger issue with Guix is the lack of maintainers. NodeJS hasn’t been updated since the last five year and Zig lacks a lot of packages. Another big issue is the centralized GNU server, which can fail at any moment. Their servers are all located in either the USA, or Europe, and for Asia, downloading NARs with such slow speed is a pain in the ass.
Those are really slow, even slower than the European ones, so I don’t bother adding them.